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KMID : 0363220170550030195
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Korean Journal of Dermatology
2017 Volume.55 No. 3 p.195 ~ p.197
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A Case of Hyalinizing Spitz Nevus: A Rare Variant in the Spectrum of Spitz Nevus
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Moon Ik-Jun
Kang Hyun-Ji
Lee Woo-Jin
Won Chong-Hyun
Chang Sung-Eun
Choi Jee-Ho
Lee Mi-Woo
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Abstract
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Hyalinizing Spitz nevus was first introduced in 1994 by Suster. It is considered a rare variant in the spectrum of Spitz nevus, with only a dozen cases having been reported to date. Herein we report a case of a 28-year-old Korean woman who had a brown papular lesion on the left palm, which was diagnosed as hyalinizing Spitz nevus. Upon histopathological investigation, discohesive growth patterns of nevus cells in a hyalinized stroma were noted. Immunohistochemical stains showed positive reactivity of nevus cells with S-100 protein and vimentin, but negative stains with HMB-45 and CD68. This case demonstrates a rare variant of Spitz nevus located on an unusual site, and calls for awareness in the diagnosis of cutaneous lesions that histologically exhibit a prominent hyalinized stroma.
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KEYWORD
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Biopsy, Differential diagnosis, Histology, Hyalinizing Spitz nevus
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